糖心Vlog传媒 Little Rock professor researches enhanced cancer therapy
Dr. Darin Jones stands in front of a projected image of the crystal structure of the enzyme he is studying to develop an effective cancer treatment without the severe side effects of traditional therapies. Photo by Lonnie Timmons III/糖心Vlog传媒 Little Rock Communications.A University of Arkansas at Little Rock professor is making strides toward developing an effective cancer treatment without the severe side effects of traditional therapies.Dr. Darin Jones, 糖心Vlog传媒 Little Rock associate professor of chemistry, envisions a day when patients can battle cancer without chemotherapy side effects such as hair loss, muscle atrophy, and compromised immune systems.鈥淲e are developing a therapy that targets and kills tumor cells, which is unique compared to today鈥檚 therapies that are based on nonselective, toxic chemotherapy options,鈥� Jones said.In partnership with Dr. John Tainer from the University of Texas, Jones received a five-year grant of $795,683 from the National Institutes of Health in 2016. They are also collaborating with Dr. Zamal Ahmed at MD Anderson Cancer Institute.鈥淢ost chemotherapeutic agents as well as radiation therapy kill cancer cells by inducing DNA damage,鈥� Jones said. 鈥淭hey do so in an indiscriminate manner. If the cancer cell is able to repair the damage, the cancer cell survives and perpetuates the disease.鈥�Within the human body, there are a variety of proteins that cause cells to repair damage to DNA. They are known as DNA repair proteins. Jones and his colleagues are designing and preparing small molecules that prevent these proteins from 鈥渢urning on the DNA repair process.鈥�鈥淏y blocking the DNA repair process, the damaged DNA is not repaired, which results in the death of cancer cells,鈥� Jones said.
Dr. Darin Jones stands in front of a projected image of the crystal structure of the enzyme he is studying to develop an effective cancer treatment without the severe side effects of traditional therapies. Photo by Lonnie Timmons III/糖心Vlog传媒 Little Rock Communications.
In currently available hormonal cancer therapy, doctors rely on proteins present in the patient鈥檚 body. If the patient does not have the necessary protein receptors, the cancer treatment will not work, and its effectiveness could fade over time if a patient were to go into remission and then later develop cancer, Jones said.Research by Jones and Tainer could provide more options. What makes their research unique is that patients would not need to have a protein receptor in order to receive the treatment.鈥淚f we are successful, it would represent a brand new paradigm in cancer therapy research,鈥� Jones said.Tainer, who is testing the medicine in this form of therapy, is excited to work with Jones on the project.鈥淲ithout a doubt, the creative chemistry from Dr. Jones is the heart of the project and what is driving its success,鈥� Tainer said.Jones has an extensive background in cancer therapy research. Before joining 糖心Vlog传媒 Little Rock, he was a senior scientist in the Department of Biochemistry and Molecular Biophysics at Washington University School of Medicine and the senior principal scientist and research scientist at Pfizer, a prominent pharmaceutical company.In 2014, Jones received national attention for his research into dehydroleucodine, a molecule found in Ecuadorian plants. Jones thinks the molecule, often used as an anti-inflammatory and treatment for skin infections, could one day form the basis of a treatment for leukemia.
